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Drug Transporters: Molecular Characterizati
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eBay-objectnummer:404695273895
Specificaties
- Objectstaat
- ISBN
- 9780471784913
- Subject Area
- Science, Medical
- Publication Name
- Drug Transporters : Molecular Characterization and Role in Drug Disposition
- Publisher
- Wiley & Sons, Incorporated, John
- Item Length
- 9.2 in
- Subject
- Life Sciences / Molecular Biology, Pharmacology, Chemistry / Industrial & Technical
- Publication Year
- 2007
- Series
- Wiley Series in Drug Discovery and Development Ser.
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Item Height
- 2 in
- Item Weight
- 50.1 Oz
- Item Width
- 6.5 in
- Number of Pages
- 890 Pages
Over dit product
Product Identifiers
Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0471784915
ISBN-13
9780471784913
eBay Product ID (ePID)
57102263
Product Key Features
Number of Pages
890 Pages
Language
English
Publication Name
Drug Transporters : Molecular Characterization and Role in Drug Disposition
Publication Year
2007
Subject
Life Sciences / Molecular Biology, Pharmacology, Chemistry / Industrial & Technical
Type
Textbook
Subject Area
Science, Medical
Series
Wiley Series in Drug Discovery and Development Ser.
Format
Hardcover
Dimensions
Item Height
2 in
Item Weight
50.1 Oz
Item Length
9.2 in
Item Width
6.5 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2006-038880
Dewey Edition
22
Series Volume Number
4
Illustrated
Yes
Dewey Decimal
572.69
Table Of Content
Contributors. Preface. 1 Overview of Drug Transporter Families (Guofeng You and Marilyn E. Morris). 2 Organic Cation Transporters (Thomas J. Urban and Kathleen M. Giacomini). 3 Organic Cation/Carnitine Transporters (Ijaz A. Qureshi, Ihsan Elimrani, Ernest Seidman, and Grant Mitchell). 4 Organic Anion Transporters (Megha Nagle, David M. Truong, Vibha Bhatnagar, Gregory Kaler, Kevin T. Bush, Wei Wu, Satish A. Eraly, and Sanjay K. Nigam). 5 Organic Anion-Transporting Polypeptides (Rommel G. Tirona and Richard B. Kim). 6 Mammalian Oligopeptide Transporters (Stephen M. Carl, Dea Herrera-Ruiz, Rajinder K. Bhardwaj, Olafur Gudmundsson, and Gregory T. Knipp). 7 Monocarboxylate Transporters (Justin A. Spanier and Lester R. Drewes). 8 Nucleoside Transporters: CNTs and ENTs (Li Xia, Mingyan Zhou, and Joanne Wang). 9 Bile Acid Transporters (Jyrki J. Eloranta and Gerd A. Kullak-Ublick). 10 Multidrug Resistance Protein: P-Glycoprotein (Frances J. Sharom). 11 Multidrug Resistance Proteins of the ABCC Subfamily (Anne T. Nies, Maria Rius, and Dietrich Keppler). 12 Breast Cancer Resistance Protein (Robert W. Robey, Orsolya Polgar, John Deeken, Kenneth K. W. To, and Susan E. Bates). 13 Drug Transport in the Liver (Pieter Annaert, Brandon Swift, Jin Kyung Lee, and Kim L. R. Brouwer). 14 Drug Transport in the Brain (Patrick T. Ronaldson, Karlo Babakhanian, and Reina Bendayan). 15 Drug Transport in the Kidney (Naohiko Anzai and Hitoshi Endou). 16 Drug Transporters in the Intestine (Yaming Su and Patrick J. Sinko). 17 Regulation of Drug Transporter Activity (Mei Hong and Guofeng You). 18 Experimental Approaches to the Study of Drug Transporters (Yoshiyuki Kubo, Yukio Kato, and Akira Tsuji). 19 In Vitro-In Vivo Scale-up of Drug Transport Activities (Kazuya Maeda and Yuichi Sugiyama). 20 Age- and Gender-Related Differences in Xenobiotic Transporter Expression (Curtis D. Klaassen and Xingguo Cheng). 21 Polymorphisms of Drug Transporters and Clinical Relevance (Leslie W. Chinn, Jason M. Gow, and Deanna L. Kroetz). 22 Diet/Nutrient Interactions with Drug Transporters (Xiaodong Wang and Marilyn E. Morris). 23 Interplay of Drug Transporters and Enzymes on Hepatic Drug Processing (K. Sandy Pang, Huadong Sun, and Shanjun Liu). 24 Clinical Relevance: Drug-Drug Interactions, Pharmacokinetics, Pharmacodynamics, and Toxicity (Serena Marchetti, Roberto Mazzanti, Jos H. Beijnen, and Jan H. M. Schellens). Index.
Synopsis
A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields., A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: Provides a comprehensive overview of drug transporters Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy Describes transporter-mediated drug disposition, a newly emerging field in drug therapy Gives a comprehensive summary of drug transport across biological membranes in the liver, brain, kidney, and intestine Provides balanced coverage of mechanistic aspects and functional outcomes Features chapters contributed by distinguished scientists in their specialty areas Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical and pharmacology fields., A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition., A comprehensive guide to drug transporters that influence the absorption, distribution, and elimination of drugs in the body The development of powerful expression cloning and genome analysis techniques has facilitated the molecular identification and characterization of numerous transporters that play a crucial role in drug disposition. Explaining the principles of drug transport and the associated techniques, Drug Transporters: Molecular Characterization and Role in Drug Disposition: * Provides a comprehensive overview of drug transporters * Includes specific descriptions of transporter families, including substrate and inhibitor specificity, subcellular and tissue localization, mechanisms governing transport, species differences, the clinical implications of these transporters in human physiology and disease, and their role in drug distribution, elimination, and interactions in drug therapy * Describes transporter-mediated drug disposition, a newly emerging field in drug therapy * Gives a comprehensive summary of drug transport across biological membranes * in the liver, brain, kidney, and intestine * Provides balanced coverage of mechanistic aspects and functional outcomes * Features chapters contributed by distinguished scientists in their specialty areas * Provides sufficient detail to enable non-specialists to understand the principles and techniques This authoritative guide is a practical hands-on desk reference for researchers in academia and the pharmaceutical industry and scientists in government agencies. It is also an excellent text for graduate-level courses in the pharmaceutical andpharmacology fields.
LC Classification Number
QP552.C34D78 2007
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