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Diabetic Cardiomyopathy
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- Nu kopenDiabetic Cardiomyopathy: Echocardiographic and Clinical Characteristics by Slavi
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Bevindt zich in: Calgary, Alberta, Canada
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Specificaties
- Objectstaat
- ISBN-13
- 9781536169577
- Book Title
- Diabetic Cardiomyopathy
- ISBN
- 9781536169577
- Series
- Cardiology Research and Clinical Developments Ser.
- Publication Year
- 2020
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Publication Name
- Diabetic Cardiomyopathy : Echocardiographic and Clinical Characteristics
- Publisher
- NOVA Science Publishers, Incorporated
- Item Weight
- 19.3 Oz
- Number of Pages
- 282 Pages
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Product Information
Background: Diabetic cardiomyopathy is defined as heart failure independent of the coronary artery, valve disease and hypertension. It has multifactorial aetiology but the pathogenesis is incompletely understood. Hyperglycemia, hyperlipidemia and inflammation with high oxidative stress lead to structural and functional alterations of the left ventricle (LV) and promote diabetic cardiomyopathy.Diastolic dysfunction is an early sign of diabetic cardiomyopathy. It has a long asymptomatic period, but with time leads to loss of contractile function. Hence, the identification of subclinical diabetic cardiomyopathy and correction of potentially modified risk factors are very important to delay the onset of heart failure.The aim: We aimed to assess the LV function in asymptomatic diabetic patients and its correlation with clinical and biochemical parameters.Study design: Cross-sectional study that includes a total number of 137 subjects. The target group consists of 72 asymptomatic normotensive patients with diabetes mellitus type 2, without coronary artery and valve disease. The control group is composed of 65 healthy subjects. Methods: All patients were subject to echocardiography (conventional 2D, M-mode, PW Doppler analysis and contemporary techniques-TDI and 2D-Speckle-Tracking Echocardiography). We evaluate LV diastolic and systolic function and its correlation with basic clinical characteristics (age, gender, BMI, BSA, waist to hip ratio, duration of diabetes) and biochemical analyses (glucose profile, lipid profile, CRP). The correlation between clinical, biochemical and echocardiographic parameters was assessed by the Pearson Product Moment of Correlation. A p-value of < 0.05 was considered to indicate significance. Results: Analysis of deformation identify the greatest number of subjects with abnormal myocardial mechanics (n=45, 62%). Wilcoxon Matched Pairs Test showed a statistically significant difference between the groups regarding the prevalence of diastolic dysfunction, in each imaging modality-PWD and TDI (Z=2.3, p=0.01; Z=2.9, p=0.003). There were strong negative correlations between clinical, biochemical and echocardiographic parameters of PW Doppler and 2D Speckle-Tracking Echocardiography and strong positive correlation with TDI.Conclusion: Doppler echocardiography is a valuable imaging technique for identifying LV dysfunction in asymptomatic patients with diabetes, and is an important part of the diagnostic algorithm in diabetic cardiomyopathy. Novel Doppler-echocardiographic techniques as are Tissue Doppler Imaging and Speckle-Tracking Echocardiography show superiority over other echocardiographic methods, regarding the early detection of LV functional abnormalities in the asymptomatic diabetic population. Its introduction in daily routine will contribute to the timely initiation of treatment of risk factors, to prevent the development of heart failure
Product Identifiers
Publisher
NOVA Science Publishers, Incorporated
ISBN-10
1536169579
ISBN-13
9781536169577
eBay Product ID (ePID)
25038627377
Product Key Features
Publication Name
Diabetic Cardiomyopathy : Echocardiographic and Clinical Characteristics
Format
Hardcover
Language
English
Series
Cardiology Research and Clinical Developments Ser.
Publication Year
2020
Type
Textbook
Number of Pages
282 Pages
Dimensions
Item Weight
19.3 Oz
Additional Product Features
Lc Classification Number
Rc660.M547 2020
Table of Content
Abstract State of the Art Epidemiology Definition of Diabetic Cardiomyopathy Aetiology Metabolic Factors Impaired Glucose Metabolism and Glucotoxicity Impaired Metabolism of Lipids and Lipotoxicity Increased Oxidative Stress, Increased the Production of Reactive Oxygen Species The Role of Transcription Factor 1 (Foxo1) To Control the Expression of Genes in the Pathogenesis of Diabetic Cardiomyopathy Pathophysiological Mechanisms in the Development of Diabetic Cardiomyopathy Pathophysiological Mechanisms in the Development of Diastolic Heart Failure Activation of Compensatory Mechanisms Diagnosis of Diabetic Cardiomyopathy Clinical Characteristics of Diabetic Cardiomyopathy Assessment of Left Ventricular Function Echocardiographic Analysis of the Left Ventricle Study Protocol Motive for Study Research Hypothesis The Aims of the Study The Specific Objective The Endpoints Project Description Design of the Project The Overall Concept of the Study Study Period Study Plan Study Population Characteristics of the Study Subjects Methodology Biochemical Analysis: The Methodology of Analysis of Selected Laboratory-Biochemical Markers of Cardiovascular Stress Clinical Study Evaluation: Statistical Analysis Dissemination and Recommendation Implementation Work Plan-Work Packages Results Comparison between the Echocardiographic Techniques in Terms of Detection of Diastolic Dysfunction Correlation between Clinical Characteristics and Echocardiographic Parameters Correlation between Demographic/Clinical Characteristics with Left Ventricular Function Correlation between Anthropometric Characteristics and Left Ventricular Function Correlations between Laboratory-Biochemical Parameters and Left Ventricular Function Correlation between the Glycemic Profile and Left Ventricular Function Correlation between Lipid Profile and Left Ventricular Function Correlation between Hyperlipidemia and Left Ventricular Function Correlation between a Marker of Inflammation CRP and Left Ventricular Function Correlation between Left Ventricular Mass and Left Ventricular Function Correlation between the Use of Statins and Left Ventricular Function Correlation between the Type of Treatment of Diabetes and Left Ventricular Function Discussion Literature.
Copyright Date
2020
Topic
Internal Medicine, Cardiology
Lccn
2019-956483
Illustrated
Yes
Genre
Medical
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