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Cytokines in Severe Sepsis and Septic Shock by H. Redl (English) Hardcover Book

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Specificaties

Objectstaat
Nieuw: Een nieuw, ongelezen en ongebruikt boek in perfecte staat waarin geen bladzijden ontbreken of ...
ISBN-13
9783764358778
Book Title
Cytokines in Severe Sepsis and Septic Shock
ISBN
9783764358778
Series
Progress in Inflammation Research Ser.
Publication Year
1998
Type
Textbook
Format
Hardcover
Language
English
Publication Name
Cytokines in Severe Sepsis and Septic Shock
Author
Gunther Schlag
Item Length
9.6in
Publisher
Springer Basel A&G
Item Width
6.7in
Item Weight
56.8 Oz
Number of Pages
Xx, 372 Pages

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Product Information

t Heinz Red! and Gunther Sch!ag Ludwig Boltzmann Institute for Experimental and Clinical Traumatology, Vienna, Austria The word "sepsis" derives from the Greek meaning decay or rottenness. Tradition­ ally this term has been used to describe the process of infection accompanied by the host's systemic inflammatory response. Based on that understanding, previous clin­ ical studies have been designed to include only patients with positive blood cultures [1, 2]. However, the frequent occurrence of a septic response without the demon­ stration of microorganisms in the circulation has led to a new definition and under­ standing of sepsis, mainly as the systemic response of the host to an often unde­ tectable microbiological or non-microbiological process [3]. The general consensus is that cytokines are central to the inflammatory response, particularly in sepsis. It is now known that not only Gram-negative but also Gram­ positive, viral, and fungal infections initiate the complex cascades of cytokine release. Probably the most important aspect of bacterial action is the release of toxic bacterial products. In particular endotoxin from Gram-negative bacteria (see chap­ ter by Schade) and super antigens (see chapter by Neumann and Holzmann), as well as pore-forming toxins [4] from Gram-positive bacteria, induce cytokine formation. The importance of this cytokine release is evident from both diagnostic and thera­ peutic (mostly experimental) studies, and the action of cytokines may be the key to our understanding of the pathophysiology of the sepsis syndrome.

Product Identifiers

Publisher
Springer Basel A&G
ISBN-10
3764358777
ISBN-13
9783764358778
eBay Product ID (ePID)
459263

Product Key Features

Author
Gunther Schlag
Publication Name
Cytokines in Severe Sepsis and Septic Shock
Format
Hardcover
Language
English
Series
Progress in Inflammation Research Ser.
Publication Year
1998
Type
Textbook
Number of Pages
Xx, 372 Pages

Dimensions

Item Length
9.6in
Item Width
6.7in
Item Weight
56.8 Oz

Additional Product Features

Number of Volumes
1 Vol.
Lc Classification Number
R1
Table of Content
Induction.- Inducers.- Endotoxin as an inducer of cytokines.- Acute lung inflammation in septic shock of the cytokine release induced by bacterial superantigens.- Lipopolysaccharide signaling pathways and their role in the development of the systemic inflammatory response syndrome.- Predisposing factors.- Predisposing factors: Effect of sex, nutritional factors and age on immunity following shock and sepsis.- Genetics: Cytokine polymorphisms.- Diagnostic.- Possibilities and problems of cytokine measurements.- Soluble TNF receptors.- Relevance of surrogate tests in intensive care patiens or "Heisenberg at the ICU".- Actions (selected events).- Nitric oxide and endothelin-1 in circulatory shock involving cytokines.- Multistep processes in neutrophil homotypic aggregation and tissue injury.- Cytokines, coagulation and fibrinolysis.- Apoptosis: Its role in the systemic inflammatory response syndrome and the involvement of cytokines.- Importance of cytokine metabolism for malnutrition, catabolism and endocrinological state in sepsis.- Therapy.- Endotoxin scavengers as a therapeutic strategy for sepsis.- Interfering with the production of cytokines in sepsis.- Neutralizing antibodies and receptor constructs.- Immunomodulation following shock and sepsis.- Gene therapy -- an alternative approach for anti-cytokine therapies.- The failure of clinical trials in sepsis.- The failure of clinical trials in sepsis: Challenges of pre-clinical models.- The failure of clinical trials in sepsis: Challenges of clinical trial design.
Copyright Date
1999
Topic
Immunology, Hematology, General
Lccn
98-037008
Dewey Decimal
616.9/44
Intended Audience
Scholarly & Professional
Dewey Edition
21
Illustrated
Yes
Genre
Medical

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