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High Resolution EPR: Applications to Metalloenzymes and Metals in Medicine by Gr

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Specificaties

Objectstaat
Nieuw: Een nieuw, ongelezen en ongebruikt boek in perfecte staat waarin geen bladzijden ontbreken of ...
ISBN-13
9781489983459
Book Title
High Resolution EPR
ISBN
9781489983459
Publication Year
2014
Series
Biological Magnetic Resonance Ser.
Type
Textbook
Format
Trade Paperback
Language
English
Publication Name
High Resolution Epr : Applications to Metalloenzymes and Metals in Medicine
Author
Lawrence Berliner
Item Length
9.3in
Publisher
Springer New York
Item Width
6.1in
Item Weight
36.8 Oz
Number of Pages
Xxv, 666 Pages

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Product Information

Metalloproteins comprise approximately 30% of all known proteins, and are involved in a variety of biologically important processes, including oxygen transport, biosynthesis, electron transfer, biodegradation, drug metabolism, proteolysis, and hydrolysis of amides and esters, environmental sulfur and nitrogen cycles, and disease mechanisms. EPR spectroscopy has an important role in not only the geometric structural characterization of the redox cofactors in metalloproteins but also their electronic structure, as this is crucial for their reactivity. The advent of x-ray crystallographic snapshots of the active site redox cofatcors in metalloenzymes in conjunction with high-resolution EPR spectroscopy has provided detailed structural insights into their catalytic mechanisms. This volume was conceived in 2005 at the Rocky Mountain Conference on Analytical Chemistry (EPR Symposium) to highlight the importance of highresolution EPR spectroscopy to the structural (geometric and electronic) characterization of redox active cofactors in metalloproteins. We have been fortunate to have enlisted internationally recognized experts in this joint venture to provide the scientific community with an overview of high-resolution EPR and its application to metals in biology. This volume, High-Resolution EPR: Applications to Metalloenzymes and Metals in Medicine, covers high-resolution EPR methods, iron proteins, nickel and copper enzymes, and metals in medicine. An eloquent synopsis of each chapter is provided by John Pilbrow in the Introduction which follows. A second volume, Metals in Biology: Applications of High-Resolution EPR to Metalloenzymes, will appear later this year covering the complement of other metalloproteins. One of the pioneers in the development of pulsed EPR and its application to metalloproteins was Arthur Schweiger, whose contribution we include in this volume. Unfortunately, he passed away suddenly during the preparation of this volume. The editors and coauthors are extremely honored to dedicate this volume to the memory of Arthur Schweiger in recognition of his technical advances and insights into pulsed EPR and its application to metalloproteins. Arthur was extremely humble and treated everyone with equal respect. He was a gifted educator with an ability to explain complex phenomena in terms of simple intuitive pictures, had a delightful personality, and continues to be sadly missed by the community. It is an honor for the editors to facilitate the dissemination of these excellent contributions to the scientific community. Suggestions for future volumes are always appreciated.

Product Identifiers

Publisher
Springer New York
ISBN-10
1489983457
ISBN-13
9781489983459
eBay Product ID (ePID)
240112927

Product Key Features

Author
Lawrence Berliner
Publication Name
High Resolution Epr : Applications to Metalloenzymes and Metals in Medicine
Format
Trade Paperback
Language
English
Publication Year
2014
Series
Biological Magnetic Resonance Ser.
Type
Textbook
Number of Pages
Xxv, 666 Pages

Dimensions

Item Length
9.3in
Item Width
6.1in
Item Weight
36.8 Oz

Additional Product Features

Series Volume Number
28
Number of Volumes
1 Vol.
Lc Classification Number
R850.A1-854
Table of Content
HIGH-RESOLUTION EPR METHODS.- Advanced Pulse EPR Methods for the Characterization of Metalloproteins.- Probing Structural and Electronic Parameters in Randomly Oriented Metalloproteins by Orientation-Selective ENDOR Spectroscopy.- Molecular Sophe: An Integrated Approach to the Structural Characterization of Metalloproteins: The Next Generation of Computer Simulation Software.- Spin-Hamiltonian Parameters from First Principle Calculations: Theory and Application.- IRON PROTEINS.- EPR of Mononuclear Non-Heme Iron Proteins.- Binuclear Non-Heme Iron Enzymes.- Probing the Structure–Function Relationship of Heme Proteins Using Multifrequency Pulse EPR Techniques.- EPR Studies of the Chemical Dynamics of NO and Hemoglobin Interactions.- NICKEL AND COPPER ENZYMES.- EPR Investigation of [NiFe] Hydrogenases.- Unique Spectroscopic Features and Electronic Structures of Copper Proteins: Relation to Reactivity.- METALS IN MEDICINE.- Insulin-Enhancing Vanadium Pharmaceuticals: The Role of Electron Paramagnetic Resonance Methods in the Evaluation of Antidiabetic Potential.- Chromium in Cancer and Dietary Supplements.- High-Frequency EPR and ENDOR Characterization of MRI Contrast Agents.
Copyright Date
2009
Topic
Materials Science / General, Diagnostic Imaging / General, Research, Chemistry / Organic, Biomedical
Dewey Decimal
538.364
Intended Audience
Scholarly & Professional
Dewey Edition
22
Illustrated
Yes
Genre
Technology & Engineering, Science, Medical

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