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ABC Transporters and Multidrug Resistance, Hardcover by Boumendjel, Ahcene (E...

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Specificaties

Objectstaat
Nieuw: Een nieuw, ongelezen en ongebruikt boek in perfecte staat waarin geen bladzijden ontbreken of ...
Book Title
ABC Transporters and Multidrug Resistance
ISBN
9780470227343
Subject Area
Medical
Publication Name
ABC Transporters and Multidrug Resistance
Item Length
9.6 in
Publisher
Wiley & Sons, Incorporated, John
Subject
Oncology, Pharmacology
Series
Wiley Series in Drug Discovery and Development Ser.
Publication Year
2009
Type
Textbook
Format
Hardcover
Language
English
Item Height
1.1 in
Author
Jean Boutonnat
Item Width
6.4 in
Item Weight
27.3 Oz
Number of Pages
480 Pages

Over dit product

Product Information

A comprehensive review of the most current scientific research on ABC transporters and multidrug resistance ATP-binding cassette transporter genes (ABC transporters) are known to play a crucial role in the development of multidrug resistance (MDR). MDR is the ability of pathologic cells, such as tumors, to withstand chemicals designed to target and destroy such cells. In MDR, patients who are on medication eventually develop resistance to not only the drug they are taking, but to several different types of drugs. ABC Transporters and Multidrug Resistance offers an essential resource for pharmaceutical researchers who are working to discover drugs to counteract multidrug resistance in diseases such as cancer. In one comprehensive volume, this book contains a collection of the most current knowledge on the involvement of ABC transporters in drug transport and resistance. This comprehensive volume provides an overview on the description of the structure, the genome, normal tissue expression, physiological aspect, and mechanism of action of the ABC protein. The expert contributors explore the expression, detection, and implications of ABC proteins in hematological malignancies and solid tumors and ABC proteins and pathogenic microorganisms. This volume also explains MDR modulation through inhibition of ABC transporters and the design of inhibitors and mechanism of action. In addition, the book offers essential information on the biological and clinical aspect of multidrug resistance.

Product Identifiers

Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0470227346
ISBN-13
9780470227343
eBay Product ID (ePID)
72342395

Product Key Features

Author
Jean Boutonnat
Publication Name
ABC Transporters and Multidrug Resistance
Format
Hardcover
Language
English
Subject
Oncology, Pharmacology
Series
Wiley Series in Drug Discovery and Development Ser.
Publication Year
2009
Type
Textbook
Subject Area
Medical
Number of Pages
480 Pages

Dimensions

Item Length
9.6 in
Item Height
1.1 in
Item Width
6.4 in
Item Weight
27.3 Oz

Additional Product Features

LCCN
2009-013351
Intended Audience
Scholarly & Professional
Series Volume Number
11
Lc Classification Number
Qp552.A87a34 2009
Reviews
"The book is both interesting for both novice and experienced researches in the field." ( ChemMedChem, July 2010)
Table of Content
PREFACE ix CONTRIBUTORS xi INTRODUCTION: WHAT IS MULTIDRUG RESISTANCE? 1 Jonathan A. Sheps and Victor Ling PART I ABC PROTEINS: AN OVERVIEW AND DESCRIPTION OF THE STRUCTURE, GENOME, NORMAL TISSUE EXPRESSION, PHYSIOLOGICAL ASPECT, AND MECHANISM OF ACTION 15 1 The P-glycoprotein 170: Just a multidrug resistance protein or a protean molecule? 17 Fabienne Grandjean-Forestier, Christophe Stenger, Jacques Robert, Mireille Verdier, and Marie-Hélène Ratinaud 2 Multidrug resistance-associated protein (MRP/ABCC proteins) 47 Mylène Honorat, Charles Dumontet, and Lea Payen 3 ABCG2: A new challenge in cancer drug resistance 83 Orsolya Polgar, Robert W. Robey, Kin Wah To, John Deeken, Patricia A. Fetsch, and Susan E. Bates PART II ABC PROTEINS AND ONCOLOGY: EXPRESSION, DETECTION, AND IMPLICATION OF ABC PROTEINS IN HEMATOLOGICAL MALIGNANCIES AND SOLID TUMORS 119 4 Expression, detection, and implication of ABC proteins in acute myeloblastic leukemia 121 Ollivier Legrand, Ruo-Ping Tang, and Jean-Pierre Marie 5 ABC proteins and oncology: Expression, detection, and implication of ABC proteins in solid tumors 143 Jean François Bernaudin, Anne Fajac, Jocelyne Fleury-Feith, Khaldoun Kerrou, and Roger Lacave PART III ABC PROTEINS AND PATHOGENIC MICROORGANISMS 177 6 ABC transporters and resistance to antibiotics 179 Serge Michalet and Marie-Geneviève Dijoux-Franca 7 ABC proteins involved in protozoan parasite resistance 195 Bruno Pradines PART IV MULTIDRUG RESISTANCE (MDR) MODULATION THROUGH INHIBITION OF ABC TRANSPORTERS: DESIGN OF INHIBITORS AND MECHANISM OF ACTION 239 8 Reversal agents for P-glycoprotein-mediated multidrug resistance 241 Hamid Morjani and Claudie Madoulet 9 Reversal agents of multidrug resistance mediated by multidrug resistance-associated proteins (MRPs) 261 Ahcène Boumendjel, Anne Florin, and Jean Boutonnat 10 Reversal agents for breast cancer resistance protein (BCRP)-mediated multidrug resistance 289 Jean Boutonnat, Anne Florin, and Ahcène Boumendjel 11 Strategies to overcome drug resistance in acute and chronic leukemias 315 Eric Solary, Vincent Ribrag, and Stéphane de Botton 12 Multidrug resistance reversal in solid tumors 349 Tatiana Bogush and Jacques Robert PART V BIOLOGICAL AND CLINICAL ASPECTS OF MULTIDRUG RESISTANCE: THE ROLE OF THE TRANSPORTERS AT THE MAIN PROTECTION BARRIERS (ABCB1, ABCC1, ABCC2, ABCG2) ON THE BIOAVAILABILITY OF MANY TYPES OF DRUGS AND MEDICATIONS 363 13 ABC superfamily transporters at the human blood-brain barrier 365 Jean-Michel Scherrmann 14 The role of ABC transporters at the intestinal barrier 385 Roos L. Oostendorp, Jos H. Beijnen, and Jan H.M. Schellens 15 Genetic polymorphisms in ABC transporters 411 Leslie W. Chinn and Deanna L. Kroetz PERSPECTIVES 437 INDEX 441
Copyright Date
2009
Dewey Decimal
572/.696
Dewey Edition
22
Illustrated
Yes

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