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Pharmacogenomi
by Ishikawa, Toshihisa; Kim, Richard B.;... | HC | Good
US $103,23
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“Missing dust jacket; Pages can have notes/highlighting. Spine may show signs of wear. ~ ”... Meer lezenover objectstaat
Goed
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Specificaties
- Objectstaat
- Goed
- Opmerkingen van verkoper
- Binding
- Hardcover
- Weight
- 1 lbs
- Product Group
- Book
- IsTextBook
- No
- ISBN
- 9780470927946
- Subject Area
- Science, Medical
- Publication Name
- Pharmacogenomics of Human Drug Transporters : Clinical Impacts
- Publisher
- Wiley & Sons, Incorporated, John
- Item Length
- 9.5 in
- Subject
- Life Sciences / Molecular Biology, Life Sciences / Genetics & Genomics, Pharmacology
- Publication Year
- 2013
- Type
- Textbook
- Format
- Hardcover
- Language
- English
- Item Height
- 1.1 in
- Item Weight
- 26.4 Oz
- Item Width
- 6.5 in
- Number of Pages
- 440 Pages
Over dit product
Product Identifiers
Publisher
Wiley & Sons, Incorporated, John
ISBN-10
0470927941
ISBN-13
9780470927946
eBay Product ID (ePID)
143597681
Product Key Features
Number of Pages
440 Pages
Language
English
Publication Name
Pharmacogenomics of Human Drug Transporters : Clinical Impacts
Publication Year
2013
Subject
Life Sciences / Molecular Biology, Life Sciences / Genetics & Genomics, Pharmacology
Type
Textbook
Subject Area
Science, Medical
Format
Hardcover
Dimensions
Item Height
1.1 in
Item Weight
26.4 Oz
Item Length
9.5 in
Item Width
6.5 in
Additional Product Features
Intended Audience
Scholarly & Professional
LCCN
2013-001312
Dewey Edition
23
Illustrated
Yes
Dewey Decimal
615.7
Table Of Content
PREFACE vii CONTRIBUTORS ix CHAPTER 1 INTRODUCTION TO PHARMACOGENOMICS OF DRUG TRANSPORTERS 1 Marianne K. DeGorter and Richard B. Kim CHAPTER 2 ADME PHARMACOGENOMICS IN DRUG DEVELOPMENT 13 Liangfu Chen and Joseph W. Polli CHAPTER 3 REGULATORY PERSPECTIVE ON PHARMACOGENOMICS OF DRUG-METABOLIZING ENZYMES AND TRANSPORTERS 39 Lei Zhang, Gilbert J. Burckart, Lawrence J. Lesko and Shiew-Mei Huang CHAPTER 4 THE PHARMACOGENOMICS OF MEMBRANE TRANSPORTERS PROJECT 73 Sook Wah Yee, Deanna L. Kroetz and Kathleen M. Giacomini CHAPTER 5 EMERGING NEW TECHNOLOGY OF SNP TYPING 109 Toshihisa Ishikawa and Yoshihide Hayashizaki CHAPTER 6 OATP1A2, OAT1, AND OAT3 125 Rommel G. Tirona CHAPTER 7 OATP1B1, OATP1B3, AND OATP2B1 141 J¨org K¨onig and Martin F. Fromm CHAPTER 8 OCT (SLC22A) AND OCTN FAMILY 171 Sophie L. Stocker, Arian Emami Riedmaier, Matthias Schwab and Kathleen M. Giacomini CHAPTER 9 MATE (SLC47) FAMILY 209 Atsushi Yonezawa and Ken-ichi Inui CHAPTER 10 PEPT (SLC15A) FAMILY 223 Tomoko Sugiura, Saki Umeda, Akira Tsuji and Yukio Kato CHAPTER 11 NUCLEOSIDE TRANSPORTERS (SLC28 AND SLC29) FAMILY 243 M´ýriam Molina-Arcas and Marc¸al Pastor-Anglada CHAPTER 12 P-GLYCOPROTEIN (MDR1/ABCB1) 271 Ingolf Cascorbi CHAPTER 13 BSEP (ABCB11) 295 Bruno Stieger and Gerd A. Kullak-Ublick CHAPTER 14 BCRP (ABCG2) 311 Agnes Basseville, Susan E. Bates, William D. Figg and Alex Sparreboom CHAPTER 15 MRP2 (ABCC2) AND MRP3 (ABCC3) 345 Anne T. Nies CHAPTER 16 MRP4 (ABCC4) 365 Satish B. Cheepala, Mugdha Sukthankar and John D. Schuetz CHAPTER 17 MRP8 (ABCC11) 387 Yu Toyoda and Toshihisa Ishikawa CHAPTER 18 FUTURE PERSPECTIVES 401 Toshihisa Ishikawa and Joseph Ware INDEX 417
Synopsis
Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers., Highlighting the internationally hot topic of pharmacogenomics and its influence on drug therapy, Pharmacogenomics of Human Drug Transporters reviews individual drug transporters, including specific transporter families and clinical implications., Sets the foundation for safer, more effective drug therapies With this book as their guide, readers will discover how to apply our current understanding of the pharmacogenomics of drug transporters to advance their own drug discovery and development efforts. In particular, the book explains how new findings in the field now enable researchers to more accurately predict drug interactions and adverse drug reactions. Moreover, it sets the foundation for the development of drug therapies that are tailored to an individual patient's genetics. Pharmacogenomics of Human Drug Transporters serves as a comprehensive guide to how transporters regulate the absorption, distribution, and elimination of drugs in the body as well as how an individual's genome affects those processes. The book's eighteen chapters have been authored by a team of leading pioneers in the field. Based on their own laboratory and clinical experience as well as a thorough review of the literature, these authors explore all facets of drug transporter pharmacogenomics, including: Individual drug transporters and transporter families and their clinical significance Principles of altered drug transport in drug-drug interactions, pharmacotherapy, and personalized medicine Emerging new technologies for rapid detection of genetic polymorphisms Clinical aspects of genetic polymorphisms in major drug transporter genes Future research directions of drug transporter pharmacogenomics and the prospect of individualized medicine Pharmacogenomics of Human Drug Transporters opens the door to new drug discovery and development breakthroughs leading to safer and more effective customized drug therapies.The book is recommended for pharmaceutical scientists, biochemists, pharmacologists, clinicians, and genetics and genomics researchers.
LC Classification Number
RM301.3.G45
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